Statistical analyses

To meet the first two objectives, the patients’ characteristics at admission and during follow-up will be presented in the form of descriptive statistics and compared between different subgroups of patients using uni- and multivariate logistic regression models. All tests will be performed with a bilateral significance level set at 5%.
To meet the third objective, repeated measures ANCOVA will be performed. In this analysis, the independent variable will be the presence or absence of GD as defined by ICD-11 criteria, while the dependent variables will be the clinical ratings (PANSS-6, CGI-S, SOFAS) measured at admission and repeated every 6 months during the patients’ follow-up. The covariates of the analysis will be: 1) the main psychiatric diagnosis; 2) the pharmacological treatment used; 3) the age and sex/gender of the patients; 4) the duration of untreated psychosis; these factors being determinant in the clinical evolution of the patients living with FEP. The results from these analyses will be performed with a bilateral significance level set at 5%.