Keywords: Biomarkers; Neuroprotection; Parkinson’s disease; miR-221
Graphical abstract: miR-221 has been found to have a protective role by regulating oxidative stress. In a cellular model of Parkinson’s disease induced by 6-OHDA, miR-221 was shown to inhibit apoptosis and promote cell viability and proliferation. Furthermore, miR-221 was found to target the PTEN gene, which is involved in regulating the AKT/mTOR signaling pathway. Overexpression of miR-221 led to increased phosphorylation of AKT, indicating activation of this pathway.