Hematopoietic Bone Marrow Transplant to Treat Systemic EBV-positive
T-Cell Lymphoma of Childhood
Abstract
Systemic EBV positive T-cell lymphoma of childhood (S-EBV-TCL) is a rare
disease for which there is no standard of care. S-EBV-TCL is often
associated with hemophagocytic lymphohistiocytosis (HLH) and is
generally thought of on the spectrum of Epstein-Barr Virus (EBV) related
disease. For the few reported cases of cure in the literature,
hematopoietic stem cell transplant (HSCT) has been required. Here, we
present the case of one patient who was successfully cured with a
modified regimen of dose adjusted EPOCH (etoposide, prednisone,
vincristine, cyclophosphamide, doxorubicin), followed by HSCT using a
reduced intensity conditioning regimen.