4 Discussion
In the present study, we investigated the effects of brief EE exposure
on glutamatergic transmission to understand whether potential
metaplastic effects underlie EE modulation of sucrose-seeking behavior
previously reported (Pintori et al. , 2022a). Our findings reveal
that 22 hours of EE exposure differently affect glutamate homeostasis in
the brain areas involved in reward and reward-related memory. These
results demonstrate that a brief EE exposure is sufficient to cause
different adaptive mechanisms that may influence glutamate receptor
availability at the synapse; such mechanisms are peculiar for each brain
region.