4 Discussion
In the present study, we investigated the effects of brief EE exposure on glutamatergic transmission to understand whether potential metaplastic effects underlie EE modulation of sucrose-seeking behavior previously reported (Pintori et al. , 2022a). Our findings reveal that 22 hours of EE exposure differently affect glutamate homeostasis in the brain areas involved in reward and reward-related memory. These results demonstrate that a brief EE exposure is sufficient to cause different adaptive mechanisms that may influence glutamate receptor availability at the synapse; such mechanisms are peculiar for each brain region.