Author Case age/ Sex Sign/symptoms Radiographic findings Laboratory Findings Treatment plan Outcome
Flores et al, 1983 [1]
61/M
Skin lesions, mild splenomegaly, cervical, axillary, and inguinal lymphadenopathy, fever, weakness, fatigue, and weight loss.
Abdominal Computed Tomography (CT) revealed retroperitoneal lymphadenopathy.
-White Blood cell (WBC), 8,200/cu mm, 26% neutrophils, 12% lymphocytes, 62% eosinophils; -Biopsies of skin lesions, liver, and lymph nodes revealed caseating granulomas with Langhans’ giant cells and eosinophils. -A Ziehl-Neelsen (ZN) stain found acid-fast bacteria. -A needle-aspirated bone marrow specimen showed eosinophil infiltration
Isoniazid, Rifampin, Ethambutol, Streptomycin
The patient’s health improved quickly.
Gill et al, 1940 [8]
19/M
Sharp chest pain, dry cough, sweating, upper abdominal discomfort, fever, and tachycardia.
Right-sided pleural effusion
- A chest fluid sample was cloudy and blood-stained, and a differential count indicated 80% eosinophil polymorphonuclear leukocytes. -Blood eosinophils 14 %
Laparotomy
The patient died eleven weeks after admission as his health worsened.
Hsu et al, 2000 [14] 66/F Chronic renal failure, bilateral neck mass growth (1–3 cm) and malaise CT showed numerous lymphadenopathies and substantial central necrosis on both neck sides. Peritoneal eosinophilia (54–85%) and peripheral eosinophilia (7–12%), pus-like material with unidentified non-fermentative Gram-negative bacilli in the biopsy. Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide About 2 weeks later, her peripheral and peritoneal fluid eosinophilia subsided.
Garg et al, 2017 [5]
68/F
Cough, fatigue, weight loss, skinny, and pale
A contrast-enhanced CT of the chest and abdomen showed enlarged non-necrotic mediastinal lymph nodes with chronic liver disease features.
-Neutrophils 41%, lymphocytes 27%, and eosinophils 32%. -Needle-aspirated bone marrow and biopsies showed increased eosinophilic -Endoscopic bronchial ultrasound-guided fine-needle aspiration of mediastinal lymph nodes showed tubercular inflammation with bacilli-positive acid-fast stain.
Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide
Eosinophil counts normalized within a week.
Haftu et al, 2020 [15]
9/F
Right upper quadrant stomach ache, decreased appetite, vomiting, weight loss, lethargy, and low-grade intermittent fever
-Abdominal Ultrasound (US) shows hepatomegaly with aberrant echo pattern and cystic change -Liver CT indicates several cystic and tiny daughter cysts as a connecting hypoechoic mass-like lesion -Leucocytosis with severe eosinophilia with 50% -The biopsy showed partially encapsulated hepatocyte lobules with many epithelioid granulomas, large cells, necrosis, and micro abscesses and chronic inflammatory cells, mostly lymphocytes and eosinophils, confirming Liver TB.
Isoniazid, Rifampicin, Ethambutol, and Pyrazinamide
After six months of Anti-Tubercular Therapy (ATT), the patient was symptom-free, gained 5 kg, and with normal lab findings.