INTRODUCTION:
Tuberculosis (TB) is still one of the most prevalent infections,
especially in the developing world. The World Health Organisation (WHO)
estimates that there are 8 million new cases annually [1,2]. Cough,
sputum with or without haemoptysis, fever, and constitutional symptoms
are the hallmark manifestations of an active tuberculosis infection. In
patients with pulmonary TB, an increase in haemoglobin levels is
regarded as an indicator of a positive response to treatment.
Furthermore, Omar et al. found that a fall in platelet count, white
blood cell (WBC) count, and erythrocyte sedimentation rate (ESR) were
strong indications of clinical response [3]. Despite the possibility
of an increase in white blood cells (WBC), which results in lymphocyte
predominance, in clinical practice, eosinophilia is a usual finding that
is self-limiting in moderate cases, but it is exceedingly infrequent in
TB [4,5].
Many allergic, viral, and neoplastic conditions may produce peripheral
blood eosinophilia, necessitating a variety of examinations and
subsequent therapy. Common causes of eosinophilia in children include
infections with helminthic parasites, allergic diseases, malignancies,
and adverse drug reactions [1,6]. One of the primary goals of the
early evaluation is to identify an underlying cause that needs specific
therapy. Even though difficulties linked with eosinophilia are more
prevalent in individuals with higher eosinophil counts
(>1500 eosinophils/uL), the peripheral blood eosinophil
count does not accurately assess the risk of organ damage in each
patient. A patient with modest peripheral blood eosinophilia may also
have significant eosinophil organ involvement. Normal eosinophil counts
in the human blood range between 0-350/mm3. This quantity accounts for
between 1 and 3% of the differential leukocyte count [7]. Most
reports of eosinophilia in tuberculosis describe local eosinophilia as
opposed to peripheral eosinophilia [8]. To the best of our
knowledge, reported cases are very rare. As a consequence, we describe
one case of TB with considerable peripheral eosinophilia and the
treatment outcome.