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\begin{document}

\title{Narrow Band Imaging reveals field cancerisation undetected by
conventional White Light: optical diagnosis versus histopathology}



\author[1]{Jeroen Westra}%
\author[1]{Manon Zwakenberg}%
\author[1]{Gyorgy Halmos}%
\author[1]{Bernard van der Laan}%
\author[2]{Bert van der Vegt}%
\author[1]{Boudewijn Plaat}%
\affil[1]{Universiteit Groningen Department of Otorhinolaryngology}%
\affil[2]{Universitair Medisch Centrum Groningen Pathologie en Medische Biologie}%


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  \date{May 25, 2024}


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\begin{abstract}
\textbf{Objective} To assess whether narrow band imaging (NBI) detects
fields of cancerisation around suspicious lesions in the upper
aerodigestive tract, which were undetected by white light imaging (WLI).
\textbf{Method} In 96 patients with laryngeal and pharyngeal lesions
suspicious for malignancy, 206 biopsies were taken during laryngoscopy:
96 biopsies of suspicious lesions detected by both WLI and NBI
(WLI+/NBI+), 60 biopsies adjacent mucosa only suspicious with NBI
(WLI-/NBI+), and 46 biopsies of NBI and WLI unsuspicious mucosa
(WLI-/NBI-) as negative controls. Optical diagnosis according to the
Ni-classification was compared with histopathology. \textbf{Results}
Signs of (pre)-malignancy were found in 88\% of WLI+/NBI+ biopsies, 32\%
of WLI-/NBI+ biopsies, and 0\% in WLI-/NBI- (p \textless{}.001). In 58\%
of the WLI-/NBI+ mucosa any form of dysplasia or carcinoma was detected.
\textbf{Conclusion} The use of additional NBI led to the detection of
(pre)-malignancy in 32\% of the cases, that would have otherwise
remained undetected with WLI alone. This highlights the potential of NBI
as a valuable adjunct to WLI in the identification of suspicious lesions
in the upper aerodigestive tract.%
\end{abstract}%



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