Figure legends:
Figure 1 Receiver operating characteristic curve for predicting survival of pancreatic cancer by various cut-off values of CA19-9(AUC=0.576, 95%CI:0.535-0.615, P=0.003). Cut-off value of CA19-9 with the maximum sensitivity + specificity for predicting survival of pancreatic cancer was 112 U/mL.
Figure 2 Overall survival curves after curative resection. (A) Patients grouped according to CA19-9 level (P <0.001, log-rank test). (B) Patients grouped according to histology grade (P <0.001). Low grade: well and moderate differentiation, high grade: poor differentiation and undifferentiation.
Figure 3 Overall survival curves after curative resection. (A) 4 groups according to the status of CA19-9 and histology grade: group 1, CA19-9≤112 U/ml and low grade; group 2, CA19-9≤112 U/ml and high grade; group 3, CA19-9>112 U/ml and low grade; group 4, CA19-9>112 U/ml and high grade. (B) 3 groups according to the biological risk score: low risk group: CA19-9≤112 U/ml and low grade; middle risk group: CA19-9≤112 U/ml+high grade or CA19-9>112 U/ml+low grade; high risk group: CA19-9>112 U/ml+high grade.
Figure 4 Overall survival curves stratified by TNM stage.The survival differences were only observed in pancreatic cancer patients with stage I and stage II disease.(A) Stage I.(B) Stage II.(C) Stage III.(D) Overall survival curves of pancreatic cancer patients according to the TNM stage and biological risk.
Figure 5 Overall survival curves of all pancreatic cancer patients. There were significant differences in OS with mTNM or TNM stage. (A) mTNM stage. (B) TNM stage.
Figure 6 Receiver operating characteristic curve for comparing the area under curves between mTNM and TNM. AUC(mTNM)=0.646, AUC(TNM) =0.587,P=0.0007.