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\begin{document}

\title{Proteomic profiling of ovarian clear cell carcinomas identifies
prognostic biomarkers for chemotherapy}



\author[1]{Liang Yue}%
\author[2]{Tingting Gong}%
\author[1]{Wenhao Jiang}%
\author[1]{Liujia Qian}%
\author[3]{Wanggang Gong}%
\author[1]{Yaoting Sun}%
\author[1]{Xue Cai}%
\author[2]{Heli Xu}%
\author[2]{Fanghua Liu}%
\author[1]{He Wang}%
\author[4]{Sainan Li}%
\author[1]{Yi Zhu}%
\author[3]{Zhi-guo Zheng}%
\author[2]{Qijun Wu}%
\author[1]{Tiannan Guo}%
\affil[1]{Westlake University}%
\affil[2]{Shengjing Hospital of China Medical University}%
\affil[3]{Zhejiang Cancer Hospital}%
\affil[4]{Peking University}%


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  \date{May 25, 2024}


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\begin{abstract}
CCOC s a relatively rare subtype of ovarian cancer with high degree of
resistance to standard chemotherapy. Little is known about the
underlying molecular mechanisms, and it remains a challenge to predict
its prognosis after chemotherapy. We analyzed the proteome of CCOC
tissue samples from two independent cohorts using DIA-MS. A total of
8697 proteins were characterized in the first cohort (H1 cohort, 32
patients, 35 FFPE samples) and 9409 proteins in the second cohort (H2
cohort, 24 patients, 28 FF samples). After bioinformatics analysis, we
narrowed our focus to 15 proteins significantly correlated with RFS in
both cohorts. These proteins are mainly involved in DNA damage response,
extracellular matrix, and mitochondrial metabolism. We further developed
a 13-protein model to predict the prognosis of patients with CCOC in H2
cohort, and validated the model in the H1 cohort in both DIA and PRM
data. Finally, we verified the modulated pathways from our CCOC
proteomic dataset in several published CCOC transcriptome and proteome
datasets. Taken together, this study presents a CCOC proteomic data
resource and a promising 13-protein panel which could potentially
predict the recurrence and survival of CCOC.%
\end{abstract}%



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\verb`Main_document_manucript_final_version_20230608-2034.docx`  available at \url{https://authorea.com/users/627401/articles/648362-proteomic-profiling-of-ovarian-clear-cell-carcinomas-identifies-prognostic-biomarkers-for-chemotherapy}

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