METHODS
EPICO-AEP is a Spanish multicenter cohort study, approved by the Ethics
Committee of Hospital 12 de Octubre (code 20/101). Eligible participants
were children diagnosed in a hospital with SARS-CoV-2 infection.
Researchers from each participating hospital collected anonymized data
using the electronic system REDCap, including epidemiological,
demographic, clinical and laboratory variables.
To assess whether there may be differences in the impact of COVID-19
depending on the type of cancer or the treatment received, categorizing
them into five groups: solid tumors, lymphoma and acute lymphoblastic
leukemia (ALL), ALL in maintenance, alloHSCT recipients within 300 days,
and alloHSCT recipients beyond 300 days.
To assess risk factors for severe COVID-19, we stratified patient
severity based on oxygen therapy requirements, a more specific and
uniform indicator of severity compared to hospitalization status.
Qualitative variables were described as number and percentage.
Quantitative variables were described as median and interquartile range
(IQR).
Categorical variables were compared using the Chi-squared test. The
comparison of continuous variables between two groups was assessed with
the Student’s t-test or Mann–Whitney U test, as appropriate. More than
two groups were analyzed with either ANOVA or Kruskal–Wallis.
Confidence intervals for all analyses were considered at 95%.
All statistical analyses were performed with R software, Version 4.2.2
(2015 The R Foundation for Statistical Computing)