Chlorhexidine gluconate (CHG) is a topical antiseptic and surgical scrub increasingly implicated in periprocedural anaphylaxis. We present four patients who had anaphylaxis in the setting of CHG exposure, an agent that has been increasingly implicated in periprocedural anaphylaxis. Catheters can be impregnated with CHG and overlooked as a source of exposure resulting in anaphylaxis.