Conclusion
Women with POI treated with systemic hormonal therapy have a vaginal
flora with a predominance of lactobacilli specifically L. crispatus and
L. iners, analyzed through molecular biology and with microbiome
obtained through the pyrosequencing of 16S rRNA, which is similar to
women with preserved gonadal function.
References
1. European Society for Human Reproduction and Embryology Guideline
Group on POI, Webber L. et al. ESHRE Guideline: Management of Women with
Premature Ovarian Insufficiency. Hum Reprod. 2016 May;31(5):926-37.
2. Ossewaarde ME, Bots ML, Verbeek AL, Peeters PH, van der Graaf Y,
Grobbee DE, van der Schouw YT. Age at menopause, cause-specific
mortality and total life expectancy. Epidemiology 2005;16:
556-562.
3. Costa GPO, Ferreira-Filho ES, Simoes RDS, Soares-Junior JM, Baracat
EC, Maciel GAR. Impact of hormone therapy on the bone density of women
with premature ovarian insufficiency: A systematic review. Maturitas.
2023 Jan;167:105-112.
4.Benetti-Pinto CL, Bedone A, Magna LA, Marques-Neto JF.
Factors associated
with the reduction of bone density in patients with gonadal dysgenesis.
Fertil Steril. 2002;77(3):571-5
5.Benetti-Pinto CL, de Almeida DM, Makuch MY.
Quality of life in
women with premature ovarian failure. Gynecol Endocrinol.
2011;27(9):645-9.
6.Roeters van Lennep JE, Heida KY, Bots ML, Hoek A, Collaborators of the
Dutch Multidisciplinary Guideline Development Group on Cardiovascular
Risk Management after Reproductive Disorders. Cardiovascular disease
risk in women with premature ovarian insufficiency: A systematic review
and meta-analysis. Eur J Prev Cardiol 2016; 23(2):178-86.
7.
Calleja-Agius
J, Brincat
MP, The urogenital system and the menopause,
Climacteric, 2015;18
Suppl 1:18-22.
8. Leining MG, Gelber S, Rosenberg R, Przypyszny M, Winer EP, Partridge
AH. Menopausal-type symptoms in young breast cancer survivors. Ann
Oncol 2006;17: 1777-1782.
9.
Amabebe
E, Anumba
DOC. The Vaginal Microenvironment:
The Physiologic Role of Lactobacilli .
Front
Med (Lausanne). 2018; 5:181.
10. Linhares IM, Giraldo PC, Baracat . EC. New findings about vaginal
bacterial flora. Rev Assoc Med Bras. 2010;6(3):370-4
11. Pacello PC, Yela DA, Rabelo S, Giraldo PC, Benetti-Pinto CL.
Dyspareunia and lubrication in premature ovarian failure using hormone
therapy and vaginal health. Climacteric. 2014 Aug;17(4):342-712. Ravel
J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S,
Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault K, Peralta L,
Forney LJ.
Vaginal microbiome of reproductive-age women. Proc Natl Acad
Sci USA 2011:108(1):4680-7.
13. Microbiome. http://en.wikipedia.org/wiki/Microbiome.05.April.2013
14. Huang YJ, Charlson ES, Collman RG, Colombini-Hatch S, Martinez FD,
Senior RM. The Role of the Lung Microbiome in Health and Disease: A
National Heart, Lung and Blood Institute Workshop Report. Am J Respir
Crit Care Med 2013 Jun 15;187(12):1382-7.
15. Priestley CJ, Jones BM, Dhar J, Goodwin L. What is normal vaginal
flora? Genitourinary Medicine. 1997;73:23–28.
16. Pybus V, Onderdonk AB. Evidence for a commensal, symbiotic
relationship between Gardnerella vaginalis and Prevotella biviainvolving
ammonia: potential significance for bacterial vaginosis. The Journal of
Infectious Diseases. 1997;175:406–413.
17. Donders GGG. Definition and classification of abnormal vaginal
flora. Best Practice & Research Clinical Obstetrics &
Gynaecology. 2007;21:355–373.
18. Döderlein A. Das scheidensekret und seine bedeutung fur
puerperalfieber. Zentralblatt fur Bakteriology. 1892;11:699.
19. Thomas S. Döderlein. Bacillus: Lactobacillus acidophilus. The
Journal of Infectious Diseases. 1928;43:218–227.
20. Farage M, Maibach H. Lifetime changes in the vulva and
vagina. Archives of Gynecology and Obstetrics. 2006;273:195–202.
21. Larsen B, Goplerud CP, Petzold CR, Ohm-Smith MJ, Galask RP. Effect
of estrogen treatment on the genital tract flora of postmenopausal
women. Obstet Gynecol. 1982;60:20–24.
22. Ginkel PD, Soper DE, Bump RC, Dalton HP. Vaginal flora in
postmenopausal women: the effect of estrogen replacement. Infectious
Diseases in Obstetrics and Gynecology. 1993;1:94–97.
23. Benetti-Pinto CL, Giraldo PC, Pacello PC, Soares PM, Yela DA.
Vaginal epithelium
and microflora characteristics in women with premature ovarian failure
under hormone therapy compared to healthy women. Arch Gynecol Obstet.
2015 Jul;292(1):159-64.
24. Hickey
RJ, Zhou
X, Pierson
JD, Ravel
J, Forney
LJ. Understanding vaginal microbiome complexity from
an ecological perspective.
Transl
Res. 2012 Oct;160(4):267-82.
25. Bakken LR. Separation and purification of bacteria from
soil. Applied and Environmental Microbiology. 1985;49:1482–1487.
26. Connon SA, Giovannoni SJ. High-Throughput Methods for Culturing
Microorganisms in Very-Low-Nutrient Media Yield Diverse New Marine
Isolates. Applied and Environmental Microbiology. 2002;68:3878–3885.
27. Stingl U, Tripp HJ, Giovannoni SJ. Improvements of high-throughput
culturing yielded novel SAR11 strains and other abundant marine bacteria
from the Oregon coast and the Bermuda Atlantic Time Series study
site. The ISME journal. 2007;1:361–371.
28. Goodman AL, Kallstrom G, Faith JJ, et al. Extensive personal human
gut microbiota culture collections characterized and manipulated in
gnotobiotic mice. Proc Natl Acad Sci U S A. 2011;108:6252–6257.
29. Park J, Kerner A, Burns MA, Lin XN. Microdroplet-enabled highly
parallel co-cultivation of microbial communities. PLoS
ONE. 2011;6:e17019.
30. (Hugenholtz P, Goebel BM, Pace NR. Impact of culture-independent
studies on the emerging phylogenetic view of bacterial diversity. J
Bacteriol. 1998;180:4765–4774.
31. Dekio I. Detection of potentially novel bacterial components of the
human skin microbiota using culture-independent molecular profiling. J
Med Microbiol. 2005;54:1231–1238.
32. Eckburg PB. Diversity of the Human Intestinal Microbial
Flora. Science. 2005;308:1635–1638.
33. Bik EM, Eckburg PB, Gill SR, et al. Molecular analysis of the
bacterial microbiota in the human stomach. Proc Natl Acad Sci U S
A. 2006;103:732–737.
34. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon
JI. The human microbiome project. Nature. 2007;449:804–810.).