Table 2
3.5 Organic solvents resistance of WT and M3
In order to verify the resistance of M3 and WT against other organic
solvents with different log P, t 1/2 values were
assayed under 25% concentration of MeOH, ACN, DMF, EtOH, IPA, and AC.
As shown in Table 3, the t 1/2 values of M3 were
longer than WT under all six organic solvents. However, thet 1/2 values of M3 were different in various
organic solvents, and the resistance of M3 against MeOH and DMF was
stronger than against ACN, EtOH, IPA, and AC. This was related to the
properties of different organic solvents, such as polarity,
permittivity, viscosity, etc.[34] Overall, M3
enhanced the stability against various organic solvents compared with WT
significantly.