Author Contributions
L.M.W. and E.D.T.W. designed the study. S.S., L.M.W., O.O.O., B.M. S.P.F. and E.D.T.W. planned and performed experiments and collected and analyzed data. M.K.M., B.M. and S.A.P. provided technical support and cared for the mouse colony. S.S., L.M.W. and E.D.T.W. wrote the manuscript, with input from all other authors. E.D.T.W. oversaw the research.