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Histologic Features and Decreased Lung FOXF1 Gene Expression in Severe Bronchopulmonary Dysplasia without a Genetic Diagnosis of Alveolar Capillary Dysplasia
  • +6
  • Steven Abman H,
  • Csaba Galambos,
  • J. Wells Logan,
  • Pawel Stankiewicz,
  • Przemyslaw Szafranski,
  • Carola Zalles,
  • Jose Gonzales,
  • Sfurti Nath,
  • Shalinkumar Patel
Steven Abman H
University of Colorado Anschutz Medical Campus

Corresponding Author:[email protected]

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Csaba Galambos
University of Colorado Anschutz Medical Campus
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J. Wells Logan
University of Florida Health at Jacksonville Nursing
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Pawel Stankiewicz
Baylor College of Medicine Department of Molecular and Human Genetics
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Przemyslaw Szafranski
Baylor College of Medicine Department of Molecular and Human Genetics
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Carola Zalles
University of Florida Jacksonville Department of Pathology and Laboratory Medicine
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Jose Gonzales
University of Florida Health at Jacksonville Nursing
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Sfurti Nath
University of Florida Health at Jacksonville Nursing
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Shalinkumar Patel
University of Florida Health at Jacksonville Nursing
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Abstract

Severe BPD can be associated with clinical and histologic features that are similar to ACD without evidence of FOXF1 genetic disease.  Importantly, lung FOXF1 and TMEM100 gene expression is markedly decreased in severe BPD, suggesting that impaired FOXF1 signaling may contribute to abnormal lung growth and refractory pulmonary hypertension in BPD.
14 Feb 2023Submitted to Pediatric Pulmonology
14 Feb 2023Submission Checks Completed
14 Feb 2023Assigned to Editor
14 Feb 2023Review(s) Completed, Editorial Evaluation Pending
20 Feb 2023Reviewer(s) Assigned
20 Mar 2023Editorial Decision: Revise Major
31 May 20231st Revision Received
02 Jun 2023Submission Checks Completed
02 Jun 2023Assigned to Editor
02 Jun 2023Review(s) Completed, Editorial Evaluation Pending
02 Jun 2023Reviewer(s) Assigned
11 Jun 2023Editorial Decision: Revise Minor
11 Jun 20232nd Revision Received
12 Jun 2023Submission Checks Completed
12 Jun 2023Assigned to Editor
12 Jun 2023Reviewer(s) Assigned
12 Jun 2023Review(s) Completed, Editorial Evaluation Pending
13 Jun 2023Editorial Decision: Accept