3 Result
Patients’ characteristics were presented in Table1 . Of the 965
study patients, the median age was 41 years (range 35-50). In the
pathology result of diagnosis before the conization, 2.5% had LSIL,
97.5% had HSIL or cervical cancer. Only a small fraction (3.7%) of the
pathological results of the conization tissue were negative for
intraepithelial lesions or malignancy (NILM), HSIL and cervical cancer
account for the majority (74.2%). The median values of cone depth and
volume were 1.80cm (range 1.30-2.30) and 1.81cm3 (rang
1.18-2.94) respectively.
We evaluated the correlation between patient characteristics and cone
margin status, we used Mann-Whitney U test and chi-square test to
evaluate the association of factors and positive margins (Table
2 ). Older age (p=0.007), the pathology result of conization tissue was
HSIL or cervical cancer (p\(<\)0.001), choose to make additional cuts
(p\(<\)0.001), smaller cone depth (p\(<\)0.001) and smaller cone volume
(p=0.01) had significantly higher rate of positive margin in total
subjects.
Multivariable logistic regression analysis revealed that making
additional cuts (odds ratio [OR], 2.480; 95%CI 1.608 to 3.826;
p=0.01), the pathology result of conization is HSIL or cervical cancer
(OR,13.203; 95%CI,6.024 to 28.936; p\(<\)0.001), age (OR,1.036; 95%CI,
1.017 to 1.054; p\(<\)0.001) and smaller cone depth (OR, 0.591; 95%CI,
0.362 to 0.965, p=0.036) were independent risk factors of positive
margin group (Fig. 2) .
Subsequently, we analyzed the additional cuts rate and the effective
additional cuts rate of doctors, who had the habit of making additional
cuts (Table 3) . In our study, a total of 64 doctors
participated in the conization surgery, and six of them (9.4%) had the
habit of making additional cuts, and four of the doctors had an
additional cuts rate greater than 80%. Of these six doctors, expect for
one doctor’s additional cut was ineffective, the rest of the doctors had
a relatively high effective additional cut rate.
Next, Table 4 shows that the cone volume in the additional cuts group
was from 0.89cm3 to 1.57cm3 (median
= 1.25cm3), there was an extremely significant
difference (p\(<\)0.001) in cone volume between the not making
additional cuts group and the making additional cuts group. On whether
the doctor had the habit of making the additional cuts group, doctors
who had the habit of making additional cuts had significantly smaller
cone volume than doctors who not had this habit (median=1.16
cm3 and 2.20 cm3, respectively;
p\(<\)0.001).