Laterite is a red weathering crust developed with various rocks and Quaternary loose sediments as its parent material in the tropics and subtropics regions of the world, and it is also the most widely distributed Quaternary earthy accumulation in China. Since the 1930s, most researchers have believed that the fluvial reticulated laterite in southern China was influenced by the warm and humid climate of the Middle Pleistocene. In recent years, the remains of Paleolithic human activities are often found in the reticulated laterite of southern China. However, the study of laterite chronology is sporadic or there is no critical chronological analysis, which causes uncertainty in the identification and discussion of the ages of reticulated laterite and Paleolithic sites in South China. In this study, a paleolithic site found in fluvial reticulated laterite in South China was systematically tested by quartz optical luminescence dating and geomorphic process analysis. The results show that, (1) The T3 terrace, an archive of hominin activity in the study area, primarily formed between 56 and 11 ka. (2) Reticulated laterite cannot be used simply to determine the ages of the Paleolithic sites found in this stratum, and typical reticulated laterite cannot be used as a marker for climatic stratigraphy and chronostratigraphy. The fluvial reticulated laterite in the southern tropics, under suitable hydrothermal conditions, can form within tens of thousands of years or even within 10 ka. (3) Human activities can also lead to an inversion in the age of reticulated red soil.