Proxy reconstructions from the mid-Holocene (MH: 6,000 years ago) indicate an intensification of the West African Monsoon and a weakening of the South American Monsoon, primarily resulting from orbitally-driven insolation changes. However, model studies that account for MH orbital configurations and greenhouse gas concentrations can only partially reproduce these changes. Most model studies do not account for the remarkable vegetation changes that occurred during the MH, in particular over the Sahara, precluding realistic simulations of the period. Here, we study precipitation changes over northern Africa and South America using four fully coupled global climate models by accounting for the Saharan greening. Incorporating the Green Sahara amplifies orbitally-driven changes over both regions, and leads to an improvement in proxy-model agreement. Our work highlights the local and remote impacts of vegetation and the importance of considering vegetation changes in the Sahara when studying and modelling global climate.