Introduction
Both impulsivity and compulsivity are psychological concepts that have increasingly gained research interest over the last years, as they are driving human behavior and are presumably involved in dysfunctional or even psychopathological behavior. While initially, they were often considered opposing ends of one spectrum , impulsivity and compulsivity are now conceptualized as two distinct, albeit correlated, personality traits .
Impulsivity can be characterized as a “predisposition toward rapid, unplanned reactions to internal or external stimuli without regard to the negative consequences of these reactions to the impulsive individual or to others” . While there are different conceptualizations of impulsivity, it is commonly described as multidimensional and encompassing cognitive (e.g., attention, planning), behavioral (e.g., motor control, risk taking) and sometimes affective (dependency on strong emotions) domains. The concrete operationalization mostly depends on the impulsivity scales used, some of which will be further described below. Compulsivity does not match the mere opposite of this definition. Instead, compulsive behavior comprises repetitive acts carried out while under a subjective loss of control thereover . Their implementation serves the purpose of preventing a negative outcome (i.e., specific feared consequences or stress and anxiety), although the agent is also on some level aware that it goes against their longer-term goals or the behavior is not suitable for reaching or even related to the intended outcome. Thus, compulsivity itself can be described as the trait facilitating this behavior.
Due to their dimensional nature, both impulsivity and compulsivity are represented to varying degrees in the general population and can have substantial effects, since they are by definition associated with potential negative outcomes: Heightened impulsivity is correlated with substance use, aggressive behavior, delinquency, gambling and risky sexual behavior, potentially leading to personal as well as societal costs . As of such, heightened impulsivity is associated with disorders like substance use disorder (SUD; , borderline personality disorder and eating disorders , primarily those associated with purging and/or bingeing. Compulsivity is predominantly examined in the context of psychopathology, as it is one of the key diagnostic criteria of obsessive-compulsive disorder (OCD; , which makes non-clinical findings scarce. A longitudinal study in Switzerland found a one-year prevalence of about 15% of subclinical obsessive-compulsive symptomatology in 591 subjects . Compulsivity can, among others, influence eating (facilitating obesity) and addictive behavior (e.g., substance use, internet use) even in healthy people, thus leading to distress. Moreover, the healthcare and socioeconomic costs of compulsive disorders are likely transferable to subclinical compulsive behavior.
Nevertheless, there is no clear distinction between “impulsive” and “compulsive” disorders. An overlap can be seen on a neuronal level, as alterations in inhibitory cortical-striatal-thalamic-cortical circuits have been found in both OCD and attention-deficit-hyperactivity disorder , which is mostly associated with impulsivity . In both OCD and various substance and behavioral addictions, compulsivity is associated with dysfunctional reward and punishment processing, learning and flexibility in favor of symptom-related stimuli that can be attributed to altered frontostriatal and limbic activation . Phenontypically, patients often show increases in both impulsivity and compulsivity in different disorders such as OCD and addictions . Furthermore, some etiological models propose e.g. substance use to originate in impulsive behavior, which then turns compulsive as the SUD chronifies . Both characteristics have been found to drive dysfunctional behavior such as compulsive exercise, overeating and alcohol use in parallel , but their interaction has so far not been resolved. Thus, transdiagnostic research is highly warranted .
Both impulsivity and compulsivity can not only be observed in complex behavior, but also on a basic behavioral level, as they involve weakened motor inhibition and are defined by premature or repetitive responses, respectively. Of particular interest here is their relationship to response inhibition, which describes the act of withholding a prepotent response in order to adapt to the present context . As such, response inhibition plays an important role in goal-directed behavior . The most prominent tasks to assess response inhibition are the Go/Nogo and the stop-signal-task (SST). Although the paradigms have been found to measure slightly different aspects of response inhibition (i.e., action selection vs. preparation of stopping) and associated neuronal processes , both are used to examine the underlying inhibitory performance. In Go/Nogo paradigms, participants are asked to respond as fast as possible to a specific stimulus (Go) but withhold their response to a different stimulus of the same modality (Nogo). Similarly, in SST, participants are asked respond quickly to a stimulus (Go) but stop the initiated response if another stimulus is presented subsequently (stop signal). Thereby response inhibition has been found to activate fronto-striatal areas, primarily the dorsal anterior cingulate cortex, right inferior frontal cortex (rIFG), presupplementary motor areas (pre-SMA), the dorsal and ventral prefrontal cortex and basal ganglia . further propose successful motor inhibition to be a top-down process driven by signaling from the rIFG to the pre-SMA. Using electroencephalographic (EEG) methods, several event-related potentials (ERP) have been linked to cognitive processes connected to response inhibition. Firstly, the N2 is a negative deflection peaking 200 ms after stimulus onset and presumably generated frontally in the midcingulate cortex and ventral and dorsolateral prefrontal cortex . In Go/Nogo tasks, it is mostly associated with novelty, or surprise (Wessel 2012), and conflict monitoring . The N2 is followed by a positive peak in the time-window around 300 ms (P3) which can be further disentangled into the frontocentral P3a and the parietal P3b. For the former, some assume the signal to mirror bottom-up attentional orienting to potentially significant or salient events , while others associate it with the pre-SMA and motor response inhibition . The P3b is assumed to reflect top-down processes of attention allocation and updating of working memory to facilitate response selection .
Combining the aforementioned measures, healthy individuals have been found to make more errors in Go/Nogo tasks when scoring higher on impulsivity measures , while other researchers have not found such an association . These findings translate to the neuropsychological correlates of response inhibition in respective tasks: Higher impulsivity is often associated with reduced P3 and enlarged N2 amplitudes . As for compulsivity, higher scores are related to more Nogo commission errors in subclinical samples . However, most findings are reported in relation to OCD, where patients are found to show longer reaction times , lower task performance and altered N2 and P3 signals in Go/Nogo paradigms. Similarly, performance on SST appears to be related to OCD and its symptom scores . However, it is unclear whether this is related to compulsivity or to other confounding measures, such as impulsivity, or if alterations rely on clinical impairments.
As stated before, impulsivity and compulsivity are two distinct features, yet share significant overlap in their neurocircuitry, associated neurocognitive abnormalities and influences on dysfunctional behaviors or even clinical impairments . Thus, further investigation of their interaction is needed to understand their impact. Moreover, the effect of impulsivity and compulsivity might have non-linear qualities (see for example ) which could contribute to the partial null findings reported above, as a potential relationship may not be apparent in linear analyses.
Accordingly, this study aimed to determine how impulsivity and compulsivity are dimensionally related to response inhibition and its electrocortical correlates in a visual Go/Nogo task in a non-clinical sample of adults. We explored the questions whether higher self-reported impulsivity is linked to lower task performance, higher amplitude of Nogo N2, and reduced amplitude of Nogo P3. Second, as the association between compulsivity and response inhibition in Go/Nogo tasks has rarely been studied outside of clinical populations, we opted for an exploratory analysis of the effect of self-reported compulsivity on task performance and event-related potentials (Nogo N2 and Nogo P3). Third, we examined how self-reported impulsivity and compulsivity interact in influencing task performance as well as event-related potentials (Nogo N2 and P3). These associations were studied in a linear as well as a non-linear fashion.
Methods
Participants
Data was collected from 253 participants from the general Dresden area. Inclusion criteria were: age 18-45 years, normal or corrected-to-normal vision and German as a native language. Participants were excluded if they reported history of neurological disease or head trauma; lifetime diagnosis of bipolar disorder, borderline personality disorder, psychotic episodes or severe alcohol use disorder; acute eating disorder or severe episode of major depression; taking psychotropic substances within the last 3 months; lifetime use of illicit substances of more than twice a year or lifetime use of cannabis of more than twice a month. One participant was excluded from further analyses due to poor task compliance (multiple responses) and two participants due two subsequent detection of exclusion criteria (regular Cannabis use in the past and German as a second language). Thus, the final sample consisted of 250 participants (49% female; age M = 25.16, SD = 5.07; education level: 94% high school or higher; self-reported lifetime diagnosis of any mental disorder: 12%).
The fit of the models obtained in the subsequent analyses was tested on a set of 43 subjects from the ongoing follow-up project (43% female; age M = 24.70, SD = 5.96; education level: 89% high school or higher). Participants did not meet diagnostic criteria for any lifetime or current mental disorders; other inclusion and exclusion criteria were identical to the subject group above.
Data analysis for this report was preregistered under https://osf.io/d4ezm/, where data and analysis routines are also accessible. The project has been approved by the ethics committee at the University Hospital Carl Gustav Carus, TUD (EK 372092017) and was conducted in accordance with the ethical guidelines of the Declaration of Helsinki. All participants gave informed consent and received financial compensation or course credit for participation. The study is part of a larger research project which assessed different cognitive control functions in relation to impulsivity and compulsivity.
Procedure and measures
Go/Nogo task
All participants completed the Go/Nogo task as part of an EEG session in the lab. In addition to the Go/Nogo task, they completed other EEG tasks as well as a neuropsychological test battery at a first lab appointment and ecological momentary assessment, which will not be reported here. The Go/Nogo task consisted of 256 trials and was divided into two blocks. Each trial started with a white circle presented on a grey background for 200-500 ms. At the center of the circle either a green square was presented as go stimulus (75% of all trials) and participants were instructed to respond as quickly as possible with their right index finger, or a red square was shown as nogo stimulus (25% of all trials) and participants were asked to withhold their response. Stimuli were presented for 500 ms and were separated by a variable inter-stimulus interval of 400-1000 ms. Nogo trials could immediately follow each other or were separated with up to five go trials.
Task performance in the Go/Nogo task was measured by nogo accuracy, reaction time (RT), and the inverse efficiency score (IES) as first introduced by : For every participant, the mean RT for correct responses was normalized by the proportion of correct responses (PC), i.e.,IES = \(\frac{\text{RT}}{\text{PC}}\). This allows for inclusion of speed (RT) as well as accuracy (PC) in a combined score.
Personality scales
Impulsivity.
Impulsivity was measured with a German translation of the 11th version of the Barratt Impulsiveness Scale (BIS-11; . Its 30 self-report items comprise attentional, motor, and non-planning impulsiveness. We used its sum score as it has shown good internal consistency (α = .83; . Further the UPPS Impulsive Behavior Scale was used . Its 59 items yield separate scores for the traits urgency, lack of premeditation, lack of perseverance and sensation seeking. As Cronbachs’s α is only reported for the separate subscales, lying between .8 and .85, we refrained from using the UPPS sum score.
Compulsivity.
The Obsessive-Compulsive Inventory-Revised (OCI-R; is a self-report measure of obsessive-compulsive symptoms, namely washing, checking, doubting, ordering, obsessing (i.e., having obsessional thoughts), hoarding, and mental neutralizing. Its 18 items result in sum score with good internal consistency (α = .85), which was used here.
EEG recording and data reduction
EEG was recorded with Ag/AgCl electrodes from 61 sites of equidistant electrode montage (Easycap GmbH, Breitbrunn, Germany) as well as from three external positions: approximately 2 cm below each eye to record eye movements and at the lower back to record the electrocardiogram. The EEG was amplified with two 32-channel BrainAmp amplifiers (Brain Products GmbH, Munich, Germany), a sampling rate of 500 Hz, and referenced to an electrode next to FCz. Offline data analysis was performed with MATLAB R2021a and EEGlab (Delorme & Makeig, 2004) using the high performance computing system (HPC) at the TU Dresden. Continuous data was filtered (0.1 – 30 Hz) and subjected to artifact removal in an adaptive fashion, removing between a single and 10 % of trials in epochs of 1.5 s. Data were submitted to an adaptive mixture independent component analysis (AMICA) and components containing eye-movement and cardioballistic artifacts were removed. Behaviorally, trials with reaction times outside the range of 70 – 600 ms were rejected. EEG data was then referenced to average reference. Stimulus-locked event-related potentials (ERP; N2, P3a, and P3b) were analyzed for correct go and nogo trials. The N2 and P3a were determined in a frontocentral electrode cluster (FCz, FC1, FC2, Cz). The N2 was defined as the most negative value in the time window 230 to 270 ms after stimulus onset and P3a as the average amplitude from 300 to 380 ms after stimulus onset. The P3b was obtained as average amplitude in the time window from 320 to 450 ms in a parietal electrode cluster (CPz, CP1, CP2, Pz, P1, P2). Baseline correction was applied in the 200 ms prior to stimulus onset.
Statistical analysis
Linear analyses
All further analyses were computed with R . The effects of impulsivity and compulsivity on the dependent variables IES, RT and Nogo accuracy as well as amplitudes of the Nogo N2, Nogo P3a and Nogo P3b were analyzed via robust linear regression. For BIS-11 and OCI-R, the respective sum scores were used as regressors in a multivariate model to uncover possible interaction effects. The UPPS scales were analyzed in a backwards stepwise fashion. Subscales were selected on their influence on the robust final prediction errors (RFPE), where those reducing RFPE were then analyzed in a robust linear regression model. The results of all linear correlation and regression analyses were tested for significance with correction of the false discovery rate as recommended by .
Gradient boosting regression trees
Gradient boosting regression trees (GBRT) are a type of decision tree, a machine-learning method used to uncover non-linear relationships between variables . Decision trees perform binary splits in the predictor space in a way that best minimizes residuals. Every split creates new segments (so called nodes), wherein the mean of the response variable serves as the predicted value. GBRT then, rather than computing a single tree, combine an ensemble of various trees based on the same training data set. The individual trees are grown sequentially, each modifying the previous version (boosting). Ultimately, model performance is enhanced by focusing on the observations that proved difficult to predict in the previous iterations. GBRT have several tuning parameters: Firstly, the number of trees B and the number of splits (interaction depth)d , which can lead to overfitting if too high. This risk is controlled by the learning rate or shrinkage parameter λ. We optimized the tuning parameters for each analysis through a grid search (see the provided R code for the range of values).
Model fit
Both the linear and the non-linear models assess the influence of impulsivity and compulsivity on different ERP and the IES. To test their accuracy, we employed two methods: Firstly, each model was created via nested cross-validation. Here, two cross-validation processes are nested into each other to allow model selection and assessment of prediction performance on the same data set. In order to do this, we divided the data into k subsets or outer loops. Nested into each of these were inner loops, which were used via cross-validation to optimize GBRT tuning parameters. The fit of the optimized model was then assessed in the outer layer. This should prevent an overly optimistic generalization error as model training and validation are separated. Second, the models were run on a test set of 43 completely separate participants. We estimated model performance through the root square mean error (RMSE ) both in the nested cross-validation process as well as for the test set prediction. These were then compared to the RMSE of the linear regression analyses. Lastly, the regression tree analyses were repeated in permutation tests with randomly assigned outcome variables to test whether the models perform above chance level.P values for the permutation test were calculated as the proportion of RMSE resulting from the permutations (N = 1000) that were lower than the actual RMSE .
Results
Behavioral results
Participants achieved an average Nogo accuracy of 0.86 (SD = 0.11) and a Go reaction time of 282 ms (SD = 30), resulting in an IES of 293 (SD = 28). See Table 1 for more details and Table 2 for questionnaire data.
Table 1. Behavioral performance