Conclusion
External validity and related concepts present unique challenges to distributed data networks due to the diverse array of populations included in analyses. Fortunately, Sentinel, CNODES, and PCORnet recognize these challenges and have developed their own solutions and analytic strategies tailored to the needs and users of the network. Still, more research needs to be done on analytic methods for addressing external validity, target populations, generalizability, and transportability within the networks.
Acknowledgements: None.