Using template matching and GPS data, we investigate the evolution of seismicity and observable deformation in Central Apennines. Seismicity appears more persistent at the base of the seismogenic layer than in the shallower crust. Diffuse activity is reported on segments at depth, alternating along strike with apparent quiescence on segments that experienced one or more Mw6+ earthquakes in 1997, 2009 and 2016. Central Apennines are likely underlain by a sizeable shear zone with areas of diffuse seismicity bounding shallow normal faults where Mw6+ earthquakes occurred. The deformation observed at the surface seems to follow the seismicity variations at the base of seismogenic layer along the Apenninic chain. Principal and independent component analysis of GPS data exhibits a transient when the 2016 foreshock sequence starts. This transient propagated northward from the Campotosto fault up to the Alto Tiberina fault system and has likely loaded the Mw6+ 2016 earthquake sequence.