Data from the South Pole ice core (SPC14) are used to constrain climate conditions and ice-flow-induced layer thinning for the last 54,000 years. Empirical constraints are obtained from the SPC14 ice and gas timescales, used to calculate annual-layer thickness and the gas-ice age difference (Δage), and from high-resolution measurements of water isotopes, used to calculate the water-isotope diffusion length. Both Δage and diffusion length depend on firn properties and therefore contain information about past temperature and snow-accumulation rate. A statistical inverse approach is used to obtain an ensemble of reconstructions of temperature, accumulation-rate, and thinning of annual layers in the ice sheet at the SPC14 site. The traditional water-isotope/temperature relationship is not used as a constraint; the results therefore provide an independent calibration of that relationship. The temperature reconstruction yields a glacial-interglacial temperature change of 6.7 ± 1.0 °C at the South Pole. The sensitivity of δ180 to temperature is 0.99 ± 0.03 ‰/°C, significantly greater than the spatial slope of ~0.8 ‰/°C that has been used previously to determine temperature changes from East Antarctic ice core records. The reconstructions of accumulation rate and ice thinning show millennial-scale variations in the thinning function as well as decreased thinning at depth compared to the results of a 1-D ice flow model, suggesting influence of bedrock topography on ice flow.