On January 15, 2022, we observed various unusual atmospheric wave events over the South American sector: Atmospheric pressure waves (Lamb mode) around 12:30 to 17:30 UT, Tsunamis along the Chile coast at around 17:00 to 19:00 UT, and related ionospheric disturbances between 11:30 and 20:00 UT. We understand that these events were generated by the Tonga volcanic eruption that occurred at (20.55°S, 175.39°W) in South Pacific Ocean at 04:15 UT. Several Traveling Ionospheric Disturbances (TIDs) were observed before and after the Lamb wave passed over the continent and the arrival of the tsunami on the Chile coast. This is the first time to report the signature of ionospheric disturbances over the South American continent generated by both the Lamb wave and the tsunami that were produced by the huge volcanic eruption.