This paper aimed to study the variation in the total ozone column amount (TOC) during the life cycle of the tropical cyclone (TC) that occurred over the northwest Indian Ocean in October 2008. The characteristics of TC tilts with vertically varying background flows were inspected preliminarily also in the current study. The vertical wind shear (VWS) was estimated as one of the most important dynamical parameters of the large-scale environment related to TC formation, structure, and intensity changes. It is found that the magnitude of VWS increased during the growth period, meanwhile, VWS weakened during the decay period. Anomalies of daily TOC have been calculated and found related to the strengthening of the cyclonic system. During the development of the tropical cyclone, an outflow develops in the upper levels with high velocities that can extend beyond tropopause up to the lower stratosphere. As a result, the lowest value of TOC during the tropical cyclone was owing to a large amount of injected water vapor from the troposphere into the stratosphere through the convection processes which was mostly photo-dissociated into OH plus atomic O by deep solar radiation in the upper and lower stratosphere leading to severe reduction of stratospheric ozone