River floodplains and reservoirs interact throughout a basin drainage network, defining a coupled human-water system with multiple feedbacks. Recent modeling developments have aimed to improve the representation of such processes at regional to continental scales. However, most large-scale hydrological models adopt simplified lumped reservoir schemes, where an offline routine is run with inflows estimated by the model, with limited consideration of the complementarity between floodplains and reservoirs on attenuating floods at regional scale. This paper presents a novel approach that fully couples river-floodplain-reservoir hydrodynamic and hydrological models, significantly improving the representation of reservoir dynamics and operation in the river-floodplain-reservoir continuum at large scale and across multiple dam cascades. The model is applied to the Paraná River Basin with explicit simulation of 31 large dams and river hydraulic variables at basin scale. Three types of reservoir bathymetry representation are compared, from lumped to distributed methods, combined with three reservoir operation schemes and varying degrees of input data requirement within two parameterization scenarios (global and regional setups). The operation schemes were more relevant than the reservoir bathymetry representation to estimate downstream flows and water levels. While the data-driven operation scheme, based on linear regressions between observed water levels and dam outflows, provided the best estimates of both active storage and discharges, the more generic operation reasonably estimated discharges and peak attenuation, albeit not as accurately for active storage. The global parameterization of reservoir operation resulted in poorer performance compared to the regional-based one, but it satisfactorily modeled discharge and peak attenuation. Regarding the reservoir bathymetry representation, a basin scale comparison of the lumped and distributed schemes indicated the inability of the former to represent backwater effects. This was further corroborated by validating the longitudinal water level profile of Itaipu dam with ICESat satellite altimetry data. Finally, the model was used to show the complementarity between floodplains and reservoirs on attenuating floods at regional scale. Large scale models should move beyond offline coupling strategies, and include regional-based, data-driven reservoir operation schemes together with a distributed representation of reservoir bathymetry into river-floodplain hydraulic schemes. This will largely improve the estimation of river discharges, water levels and flood storage, and thus the model ability to represent the regional scale river-floodplain-reservoir continuum.