The current study aimed at assessing the capabilities of five machine learning models in term of mapping tungsten polymetallic prospectivity in the Gannan region of China. The five models include logistic regression (LR), support vector machine (SVM), random forest (RF), convolutional neural network (CNN), and light gradient boosting machine (LGBM) models. Geochemical, lithostratigraphic, and structural datasets were used to generate 16 evidential maps, which were integrated into the machine learning models. Tungsten polymetallic deposits were randomly separated into two parts: 80% for training and 20% for validating. Performances of the models were evaluated through receiver operating characteristic (ROC) and K-fold cross validation, with an emphasis on the variable influence within different machine learning methods. The results show that the models are especially sensitive to the chemical elements: Be, Bi, Pb and Cd, implying that these are closely related to tungsten polymetallic mineralization. Compared to other models, the LGBM and CNN models performed best, while the LR model was the most stable. The results also indicated that the CNN model can predict maximum known deposits within a minimum area, based on the prediction-area plot analysis of the five models, while the RF model can capture the most well-known deposits within the smallest study area. Finally, eighteen prospective areas were delineated according to the predicting results of the machine learning models, which will provide important guidance for further tungsten polymetallic exploration and associated studies.