Cohesive properties of clay promote the formation of clay flocs and gels and relatively small suspended clay concentrations can enhance or suppress turbulence in a flow. Flows are naturally non-uniform, varying in space and time, yet the dynamics of non-uniform open-channel clay suspension flows are poorly understood. To research the influence of suspended cohesive clay on changing flow dynamics under non-uniform flow conditions, new experiments were conducted using decelerating and accelerating clay suspension open-channel flows in a recirculating flume. The flows transition between clay flow types, with different degrees of turbulence enhancement and attenuation as the flow adapts to the change in velocity. The experimental results show that decelerating clay suspension flows have a longer adaptation time than accelerating clay suspension flows. The formation of bonds between cohesive sediment particles is a time-dependent process and establishing clay bonds, as in the decelerating flows, requires more time than breaking them, as in the accelerating flows. This hysteresis is more pronounced for higher concentration decelerating flows that pass through a larger variety of flow phases of turbulence enhancement and attenuation. These different adaptation time scales and associated clay flow type transitions are likely to affect erosional and depositional processes in a variety of fluvial and submarine settings.