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Current surgical Approach: Rhabdomyosarcoma
  • +4
  • Timothy Rogers,
  • Andreas Schmidt,
  • Amanda F. Buchanan,
  • Thomas Scharschmidt,
  • Roshni Dasgupta,
  • Ekene A. Onwuka,
  • David Rodeberg
Timothy Rogers
University Hospitals Bristol and Weston NHS Foundation Trust
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Andreas Schmidt
University Children's Hospital University of Tüebingen
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Amanda F. Buchanan
University of Kentucky Albert B Chandler Hospital
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Thomas Scharschmidt
Nationwide Children's Hospital
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Roshni Dasgupta
Cincinnati Children's Hospital Medical Center Winslow
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Ekene A. Onwuka
Texas Children's Hospital Pediatric Hospital Medicine
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David Rodeberg
University of Kentucky College of Medicine

Corresponding Author:[email protected]

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Abstract

Rhabdomyosarcoma (RMS) is a tumor primarily of mesenchymal origin that comprises approximately half of all pediatric sarcomas, which make up 7% of all pediatric tumors. The focus of this manuscript will include recent changes in surgical and local control therapy of RMS. We will discuss surgical therapy principles including improved outcomes associated with complete surgical resection of the primary tumor either prior to the initiation of chemotherapy or after induction of chemotherapy, and in the setting of metastatic disease. We will also discuss the increasing utilization of core needle biopsy for diagnosis and the use of sentinel node biopsy techniques to determine the presence of nodal disease. There have been refinements regarding optimal prognostic factors including the adoption of fusion status over histology, as well as updated risk stratification schemas to assure optimal therapy. Since this manuscript is an international collaboration, part of the discussion will also focus on comparisons between North American and European surgical paradigms.
02 Jun 2024Submitted to Pediatric Blood & Cancer
03 Jun 2024Submission Checks Completed
03 Jun 2024Assigned to Editor
04 Jun 2024Reviewer(s) Assigned
18 Jun 2024Review(s) Completed, Editorial Evaluation Pending
18 Jun 2024Editorial Decision: Revise Major
28 Aug 20241st Revision Received
28 Aug 2024Submission Checks Completed
28 Aug 2024Assigned to Editor
28 Aug 2024Review(s) Completed, Editorial Evaluation Pending
28 Aug 2024Reviewer(s) Assigned
14 Sep 2024Editorial Decision: Revise Minor
04 Oct 2024Assigned to Editor
04 Oct 2024Submission Checks Completed
04 Oct 20242nd Revision Received
09 Oct 2024Review(s) Completed, Editorial Evaluation Pending
09 Oct 2024Reviewer(s) Assigned
16 Oct 2024Editorial Decision: Revise Minor