Results
A total of 66 patients with melanoma were seen by the GPC during the
study period, with 38 (57.6%) electing to undergo germline genetic
testing. The average age at melanoma diagnosis was 11.2 years. The
majority were white (n= 36, 95%). Diagnoses included malignant melanoma
(MM, n=19; 50%), spitzoid melanoma (SM, n=14; 37%), and uveal melanoma
(UM, n=5; 13%). Thirty-two patients were newly diagnosed whereas six
patients developed melanoma as a subsequent neoplasm. Eight patients
(21%) had a positive family history of melanoma (Table 1 ).
Thirteen patients (34%) underwent broad cancer germline sequencing of
63–115 genes and the remainder had targeted melanoma gene panels.
Overall, five patients (13%) harbored pathogenic or likely pathogenic
GVs (Table 2 ).