References
1. Feldstein LR, Rose EB, Horwitz SM,
et al. Multisystem Inflammatory Syndrome in U.S. Children and
Adolescents. The New England journal of medicine.2020;383(4):334-346.
2. Letícia de Oliveira Toledo S, Sousa
Nogueira L, das Graças Carvalho M, Romana Alves Rios D, de Barros
Pinheiro M. COVID-19: Review and hematologic impact. Clinica
chimica acta; international journal of clinical chemistry.2020;510:170-176.
3. Diorio C, McNerney KO, Lambert M,
et al. Evidence of thrombotic microangiopathy in children with
SARS-CoV-2 across the spectrum of clinical presentations. Blood
advances. 2020;4(23):6051-6063.
4. Consiglio CR, Cotugno N, Sardh F,
et al. The Immunology of Multisystem Inflammatory Syndrome in Children
with COVID-19. Cell. 2020;183(4):968-981.e967.
5. Wahlster L, Weichert-Leahey N,
Trissal M, Grace RF, Sankaran VG. COVID-19 presenting with autoimmune
hemolytic anemia in the setting of underlying immune dysregulation.Pediatric blood & cancer. 2020;67(9):e28382.
6. Caso F, Costa L, Ruscitti P, et al.
Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory
mechanisms in genetically predisposed subjects? Autoimmunity
reviews. 2020;19(5):102524.
7. Mantovani Cardoso E, Hundal J,
Feterman D, Magaldi J. Concomitant new diagnosis of systemic lupus
erythematosus and COVID-19 with possible antiphospholipid syndrome. Just
a coincidence? A case report and review of intertwining pathophysiology.Clinical rheumatology. 2020;39(9):2811-2815.
8. Najafi S, Rajaei E, Moallemian R,
Nokhostin F. The potential similarities of COVID-19 and autoimmune
disease pathogenesis and therapeutic options: new insights approach.Clinical rheumatology. 2020;39(11):3223-3235.
9. Zenno A, Richardson M. Coombs
Positive Thrombotic Thrombocytopenic Purpura in a Male Pediatric
Patient: An Urgent Diagnostic Challenge. Pediatric blood &
cancer. 2016;63(10):1860-1862.
10. Reese JA, Muthurajah DS, Kremer
Hovinga JA, Vesely SK, Terrell DR, George JN. Children and adults with
thrombotic thrombocytopenic purpura associated with severe, acquired
Adamts13 deficiency: comparison of incidence, demographic and clinical
features. Pediatric blood & cancer. 2013;60(10):1676-1682.
11. Lazarian G, Quinquenel A, Bellal
M, et al. Autoimmune haemolytic anaemia associated with COVID-19
infection. British journal of haematology. 2020;190(1):29-31.
12. Fayyaz A, Igoe A, Kurien BT, et
al. Haematological manifestations of lupus. Lupus science &
medicine. 2015;2(1):e000078.
13. Brunner HI, Freedman M, Silverman
ED. Close relationship between systemic lupus erythematosus and
thrombotic thrombocytopenic purpura in childhood. Arthritis and
rheumatism. 1999;42(11):2346-2355.
14. Xu S, Chen M, Weng J. COVID-19
and Kawasaki disease in children. Pharmacological research.2020;159:104951.
15. Wiernek SL, Jiang B, Gustafson
GM, Dai X. Cardiac implications of thrombotic thrombocytopenic purpura.World journal of cardiology. 2018;10(12):254-266.
Figures and tables legends Figure 1 A Peripheral blood smear at presentation: Red blood
cells (RBC) with numerous schistocytes and spherocytes with rare
basophilic stippling and significant polychromasia. The platelets were
markedly decreased in number with few large in size. White blood cells
(WBC) were morphologically normal with activationFigure 1 B Peripheral blood smear following treatment: RBC with
mild polychromachia and occasional schistocytes averaged 2-3 per high
power field, but otherwise normal morphology. Platets and WBC are number
and morphologically normal.Table 1. Summary of laboratory finding comparing presentation
and following treatment