We present a Python package geared towards the intuitive analysis and visualization of paleoclimate timeseries, Pyleoclim. The code is open-source, object-oriented, and built upon the standard scientific Python stack, allowing users to take advantage of a large collection of existing and emerging techniques. We describe the code’s philosophy, structure and base functionalities, and apply it to three paleoclimate problems: (1) orbital-scale climate variability in a deep-sea core, illustrating spectral, wavelet and coherency analysis in the presence of age uncertainties; (2) correlating a high-resolution speleothem to a climate field, illustrating correlation analysis in the presence of various statistical pitfalls (including age uncertainties); (3) model-data confrontations in the frequency domain, illustrating the characterization of scaling behavior. We show how the package may be used for transparent and reproducible analysis of paleoclimate and paleoceanographic datasets, supporting FAIR software and an open science ethos. The package is supported by an extensive documentation and a growing library of tutorials shared publicly as videos and cloud-executable Jupyter notebooks, to encourage adoption by new users.