loading page

Population-based hospitalization burden estimates for respiratory viruses, 2015-2019
  • +10
  • Richard Zimmerman,
  • GK Balasubramani,
  • Helen D'Agostino ,
  • Lloyd Clarke ,
  • Mohamed Yassin,
  • Donald Middleton ,
  • Fernanda Silveira,
  • Nicole Wheeler ,
  • Jonathan Landis ,
  • Alanna Peterson ,
  • Joe Suyama ,
  • Alexandra Weissman ,
  • Mary Patricia Nowalk
Richard Zimmerman
University of Pittsburgh

Corresponding Author:[email protected]

Author Profile
GK Balasubramani
University of Pittsburgh
Author Profile
Helen D'Agostino
University of Pittsburgh
Author Profile
Lloyd Clarke
UPMC
Author Profile
Mohamed Yassin
UPMC Health System
Author Profile
Donald Middleton
UPMC Saint Margaret
Author Profile
Fernanda Silveira
University of Pittsburgh
Author Profile
Nicole Wheeler
UPMC Passavant
Author Profile
Jonathan Landis
UPMC Passavant
Author Profile
Alanna Peterson
UPMC Shadyside
Author Profile
Joe Suyama
UPMC Magee-Women's Hospital
Author Profile
Alexandra Weissman
UPMC Magee-Women's Hospital
Author Profile
Mary Patricia Nowalk
University of Pittsburgh
Author Profile

Abstract

Background: Acute respiratory infections (ARIs) result in millions of illnesses and hundreds of thousands of hospitalizations annually in the US. The responsible viruses include influenza, parainfluenza, human metapneumovirus, coronaviruses, respiratory syncytial virus (RSV), and human rhinoviruses. This study estimated the population-based hospitalization burden of 18 respiratory viruses (RV) over 4 years, from 7/1/2015 to 6/30/2019 among adults ≥18 years of age for Allegheny County (Pittsburgh), Pennsylvania. Methods: We used population-based statewide hospital discharge data, health system electronic medical record (EMR) data for RV tests, census data, and a published method to calculate burden. Results: Among 26,211 eligible RV tests, 67.6% were negative for any virus. The viruses detected were rhinovirus/enterovirus (2,552; 30.1%), influenza A (2,299; 27.1%), RSV (1,082; 12.7%), human metapneumovirus (832; 9.8%), parainfluenza (601; 7.1%), influenza B (565; 6.7%), non-SARS-CoV-2 coronavirus (420; 4.9% 1.5 years of data available), and adenovirus (136; 1.6%). Most tests were among female (58%) and white (71%) patients with 60% of patients ≥65 years, 24% 50-64 years and 16% 18-49 years. The annual burden, ranged from 137-174/100,000 population for rhinovirus/enterovirus; 99-182/100,000 for influenza A; 56-81/100,000 for RSV. Among adults <65 years, rhinovirus/enterovirus hospitalization burden was higher than influenza A; whereas the reverse was true for adults ≥65 years. RV hospitalization burden increased with increasing age. Conclusions: These virus-specific ARI population-based hospital burden estimates showed significant non-influenza burden. These estimates can serve as the basis for several areas of research that are essential for setting funding priorities and guiding public health policy.
16 Jun 2022Submitted to Influenza and other respiratory viruses
11 Jul 2022Submission Checks Completed
11 Jul 2022Assigned to Editor
16 Jul 2022Editorial Decision: Accept
Nov 2022Published in Influenza and Other Respiratory Viruses volume 16 issue 6 on pages 1133-1140. 10.1111/irv.13040