Residue Interaction network analysis
The protein conformations were visualized in Chimera [81] and interaction networks were obtained using Structure Viz [82], a Cytoscape [83] plugin, having contacts with default parameters set as criteria for building the network which was visualized using Cytoscape. Topological analysis like betweenness centrality (BC), closeness centrality (CC) were calculated using CytoNCA [84], another cytoscape plugin, each giving inputs regarding the functionally relevant residues. Also Z-score for BC & CC were calculated using the formula, z = (x-μ)/ σ, where x is the actual value, μ is the mean of the dataset, and σ is the standard deviation of the dataset.