Data and Software Availability
GROMACS, Cytoscape, Chimera, VMD are freely available software, while CHARMM-GUI is a free web server. Origin Lab, software used for making figures were obtained through institutional license provided by Indian institute of Technology, (B.H.U) Varanasi. System modeling and analysis procedures are given in the methods section. The plots showing the principal components data, time evolution of secondary structure , residue interaction networks of lowest energy conformations of tau & glycan structure used for N-glycosylation of the tau protein is given in supporting information .The movies which shows the motion of tau peptides along the first two eigenvectors are also given in the supporting information.