Patients
In the multicenter clinical trial CoALL08-09 accrual was open from 1
October 2010 to 31 December 2019. A total of 745 patients aged
>1 and < 18 years were enrolled in 8 cooperating
trial centers in Germany. The study was approved by the ethics committee
of the city of Hamburg and the institutional review boards of every
individual trial center. Written informed consent was obtained from
patients’ parents or guardians in each case. The trial was registered at
the ClinicalTrials.gov data base: GPOH-COALL 08-09 EU-21076 /NCT 0122
8331.