Model
A literature review was performed to identify population PK models for
intravenous tobramycin in CF adult patients. Models were included in
this study if they were developed with NONMEM® software (Icon
Development Solutions, Ellicott City, MD, USA) and if associated
covariates were consistent with our collected data. Models were excluded
if not enough data was provided to characterize the structural model.
Previously published models were implemented on NONMEM® version 7.4.4.
Visual evaluation of plots was conducted using R (version 3.5.1). An
analysis of goodness of fit plot was performed to assess model validity.
Indicators, according to the method of Varvel et al., were then
calculated(11). The relative performance error (PEij[%] for the ith individual at the jth tobramycin concentration) was
compared to the predicted concentration (Cpred ij) with
the corresponding observations (Cobs ij) – Equation 1 :