Statistical analysis
The study cohort was categorized into those who achieved a positive treatment outcome and those who did not; these two groups were compared using a Chi-square test or a Student’s t-test, as appropriate, with regards to demographic and APE variables. Levene’s test was used to determine if equality of variance was to be assumed for continuous variables. A 2-sided α of 0.05 and/or a 95% confidence interval (CI) was used in all analysis. Doses were converted from mg to mg/kg to account for weight differences between patients. Antibiotic combinations administered in concomitance to tobramycin were given their own category if they were used in 5% or more cases, otherwise, they were included in the « other » category. A multivariable logistic regression analysis was performed for determination of risk factors for therapeutic failure. All variables of clinical interest that differed between groups were forced into the model to account for variability. Microorganism susceptibility was also included. The Matouk Score was the only variable assessing the severity of the APE included in the analysis. All statistical analyses were performed on SPSS version 27.