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Longitudinal assessment of maternal depression and later life childhood asthma and wheeze: effect modification by child sex
  • +9
  • Cecilia Sara Alcala,
  • Paloma Orozco Scott,
  • Marcela Tamayo-Ortiz,
  • Carmen Hernández,
  • Lourdes Schnaas,
  • Kecia N. Carroll,
  • Megan Niedzwiecki,
  • Robert O. Wright,
  • Martha Maria Téllez-Rojo,
  • Rosalind J Wright,
  • Hsiao-Hsien Leon Hsu,
  • Maria Jose Rosa
Cecilia Sara Alcala
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health

Corresponding Author:[email protected]

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Paloma Orozco Scott
Icahn School of Medicine at Mount Sinai Department of Medicine
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Marcela Tamayo-Ortiz
Occupational Health Research Unit Mexican Social Security Institute Mexico City Mexico
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Carmen Hernández
National Institute of Perinatology Mexico City Mexico
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Lourdes Schnaas
Department of Developmental Neurobiology National Institute of Perinatology Mexico City Mexico
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Kecia N. Carroll
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Megan Niedzwiecki
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Robert O. Wright
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Martha Maria Téllez-Rojo
Center for Nutrition and Health Research National Institute of Public Health Cuernavaca Morelos Mexico
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Rosalind J Wright
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Hsiao-Hsien Leon Hsu
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Maria Jose Rosa
Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health
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Abstract

Background: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. Methods: Maternal depression (n=605) were assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) a) during pregnancy, b) postpartum, and c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using a validated survey at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models. Results: Both postpartum and recurrent depression were associated with higher risk of current wheeze (RR: 1.88, 95% CI: 1.21, 2.92; RR: 2.39, 95% CI: 1.52, 3.78) and asthma at 48 months (RR: 2.79, 95% CI: 1.13, 6.87; RR: 3.14, 95% CI: 1.26, 7.84). In interaction analyses, associations were stronger in females. Postpartum and recurrent depression were associated with higher risk of current wheeze at 48 months in females (RR: 3.06, 95% CI: 1.48, 6.32; RR: 4.02, 95% CI: 1.91, 8.46) when compared to males RR: 1.47, 95% CI: 0.84, 2.56; RR: 1.86, 95% CI: 1.04, 3.34). Conclusions: Postpartum and recurrent depression were associated with higher risk of wheeze and asthma in children, and associations were stronger in females than males. Understanding the temporal- and sex-specific effects of maternal depression may better inform prevention strategies.
29 Apr 2022Submitted to Pediatric Pulmonology
29 Apr 2022Submission Checks Completed
29 Apr 2022Assigned to Editor
30 Apr 2022Reviewer(s) Assigned
11 May 2022Review(s) Completed, Editorial Evaluation Pending
20 May 2022Editorial Decision: Revise Major
15 Aug 20221st Revision Received
25 Aug 2022Submission Checks Completed
25 Aug 2022Assigned to Editor
25 Aug 2022Reviewer(s) Assigned
31 Aug 2022Review(s) Completed, Editorial Evaluation Pending
05 Sep 2022Editorial Decision: Revise Minor
06 Sep 20222nd Revision Received
12 Sep 2022Submission Checks Completed
12 Sep 2022Assigned to Editor
12 Sep 2022Reviewer(s) Assigned
16 Sep 2022Review(s) Completed, Editorial Evaluation Pending
17 Sep 2022Editorial Decision: Accept