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Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma
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  • Hiroki Ishii,
  • Takahiro Tsujikawa,
  • Naoki Oishi,
  • Arisa Kinouchi,
  • Kaname Sakamoto,
  • Junichi Mitsuda,
  • Hiroshi Ogi,
  • Kyoko Itoh,
  • Tetsuo Kondo,
  • Shigeru Hirano,
  • Daiju Sakurai
Hiroki Ishii
University of Yamanashi

Corresponding Author:[email protected]

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Takahiro Tsujikawa
Kyoto Prefectural University of Medicine
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Naoki Oishi
University of Yamanashi
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Arisa Kinouchi
University of Yamanashi
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Kaname Sakamoto
University of Yamanashi
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Junichi Mitsuda
Kyoto Prefectural University of Medicine
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Hiroshi Ogi
Kyoto Prefectural University of Medicine
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Kyoko Itoh
Kyoto Prefectural University of Medicine
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Tetsuo Kondo
University of Yamanashi
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Shigeru Hirano
Kyoto Prefectural University of Medicine
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Daiju Sakurai
University of Yamanashi
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Abstract

Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer that has no effective drugs. Herein, we report that comprehensive cancer mutation analysis revealed amplification of CD274 gene encoding PD-L1. Multiplex immunohistochemistry also clarified the presence of an immunosuppressive microenvironment via a PD-1/PD-L1 pathway in metastatic ITTC.

Peer review status:Published

20 Mar 2022Submitted to Clinical Case Reports
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22 Mar 2022Submission Checks Completed
22 Mar 2022Assigned to Editor
10 Apr 2022Reviewer(s) Assigned
07 May 2022Review(s) Completed, Editorial Evaluation Pending
10 May 2022Editorial Decision: Revise Minor
18 May 20221st Revision Received
20 May 2022Submission Checks Completed
20 May 2022Assigned to Editor
20 May 2022Review(s) Completed, Editorial Evaluation Pending
23 May 2022Editorial Decision: Accept
Jul 2022Published in Clinical Case Reports volume 10 issue 7. 10.1002/ccr3.6050