Immunophenotypic shifts during minimal residual evaluation in a case of
leukemic form of Anaplastic large cell lymphoma ALK+
Abstract
This study aims to describe immunophenotypic studies at diagnosis and
follow up of a pediatric patient with leukemic phase of ALK+ anaplastic
large cell lymphoma (ALCL) by multiparametric flow cytometry (MFC). An
8-color MFC combination of antibodies allowed to identify neoplastic
cells in concentrations until 0.02% during minimal residual disease
(MRD) monitoring. Immunophenotypic shifts occurred in key markers as
CD30, CD7, CD2 and CD5, however neoplastic cells were clearly
discriminated from normal populations. MFC can be a useful tool for ALCL
diagnosis and MRD monitoring and may support therapeutic decisions.