Alopecia totalis (AT) is a chronic disease that results in non-scarring hair loss of the entire scalp. This results from an autoimmune reaction involving the hair follicles due to genetic and environmental factors. The clinical course of AT is highly unpredictable. There are limited effective durable treatment options. Resolution of alopecia has been reported post-autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, no cases of AT remission following chemotherapy alone have been described. Here, we present a case of complete remission of AT following chemotherapy for B-cell acute lymphoblastic leukemia (B-ALL) in a pediatric patient.