Outcome of childhood acute lymphoblastic leukemia treatment in a single
center in Brazil: a survival analysis study
Abstract
Bacgrond: acute lymphoid leukemia (ALL) is the most common neoplasm in
childhood. The probability of current overall survival is around 90% in
developed countries. There are few studies that demonstrate the results
in Brazil. This work aims to analyze the results of children with ALL
treated at a single institution in Rio de Janeiro. Procedure:
retrospective analysis survival study of a cohort of childhood ALL
patients treated in Hemorio. Kaplan-Meier and log-rank methods were used
for analysis of overall survival (OS) and events free survival (EFS) and
the Cox proportional hazards regression model for multivariate analysis.
Results: the probability of OS and EFS at 6 years was 52% and 45%. The
probability of OS and EFS in 6 years for pacients aged 10-17 years was
31% and 28% and for the younger was 65% and 55% respectively
(p<0.001). A probability of OS and EFS in 6 years for patients
with more than 100.000 leukocytes/mm3 at diagnosis was 19% and 16% and
those with less than 100.000 was 62% (p=0.007) and 55% (p= 0.008).
Those who received less than 10 doses of native Echerichia coli
asparaginase had a probability of OS and EFS in 6 years of 27% and 21%
and that who received at least 10 doses was 74% and 65%
(p<0.001). Conclusions: the presence of a high number of
adolescents and high-risk patients, as well as many patients who
discontinueted the use of asparaginase or any substitute led to a lower
probability of OS and EFS in our cohort.