Aiming at the problem of crosstalk between microstrip lines, a method of reducing crosstalk by using Cross-Shape Resonators (CSR) structures is proposed. On the premise of not changing the spacing of microstrip lines, this method adds CSR structures between the coupled microstrip lines to increase the capacitive coupling and thus to suppress the far-end crosstalk. Based on the analysis of the equivalent circuit of CSR structure, the parameters simulation and verification are carried out by ADS and HFSS software. Through HFSS simulation and physical test of the designed CSR structure, the results show that: the CSR structure can significantly reduce the far-end crosstalk by about 15 dB in the frequency of 0~10GHz, and the maximum can reach 43 dB. Compared with 3W crosstalk reduction method and RectangularShape Resonators (RSR) crosstalk reduction method, the crosstalk reduction effect is improved.