Introduction:
The Coronavirus 19 (COVID-19) pandemic has had significant implications for patients with chronic medical conditions, particularly those who are immunocompromised due to malignancy or bone marrow failure (BMF). Shwachman-Diamond syndrome (SDS) is an inherited BMF disorder characterized by cytopenias, particularly neutropenia, exocrine pancreatic dysfunction, and predisposition to myeloid malignancies. Its manifestations are variable and can affect many body systems, including the skeletal, cardiac, endocrine, nervous, hepatic, and immune systems. In most cases SDS is due to recessive mutations in the Shwachman-Bodian-Diamond Syndrome (SBDS ) gene located on chromosome 7q11. Because patients with SDS can experience neutropenia due to BMF, they carry a higher risk for serious infections compared to the general population; however, it has been unknown whether this predisposes them to developing COVID-19 or experiencing greater complications related to COVID-19.