Second Cancer Risk in Childhood Cancer Survivors Treated With
Intensity-Modulated Radiation Therapy (IMRT): An Updated Analysis of
More Than 10 Years of Follow-Up
Abstract
Background It is unclear how intensity-modulated radiation therapy
(IMRT) impacts long-term risk of second malignant neoplasms (SMNs) in
childhood cancer patients. Procedure Patients aged 10 years, many solid
SMNs after IMRT in childhood cancer survivors develop in the high dose
region. These data serve as a foundation for comparison with other
modalities of radiation treatment (e.g., proton therapy).