Brucellosis is a zoonotic infection often associated with osteoarticular involvement. In the current report, we described a case of brucellosis-induced avascular necrosis (AVN) of the hip. A 28-year-old rural female with a chief complaint of right lower limb claudication for two weeks was admitted into the infectious disease ward. She was diagnosed with brucellosis one month ago, for which she received standard medications. Her brucellosis was confirmed via serological tests, i.e., Wright’s test, 2-mercaptoethanol (2ME), and Coombs Wright. Because of her right lower limb claudication and reduced range of motion in the right hip joint, pelvic radiography was performed, indicating AVN. Then, this clinical suspicion was further confirmed by ultrasound (US) and magnetic resonance imaging (MRI) of the hip. Because of the unreversible damage to the head of her right femur, a total hip replacement surgery was suggested for this patient after consultation with an orthopedic surgeon. Then, she was discharged from the hospital after her arthralgia had improved, and she could walk without aid. Brucellosis is considered a thousand face infection due to its long-lasting side effects. Therefore, in endemic regions, more attention should be paid to suspected cases of brucellosis for any diagnosing and treating any common or uncommon complications.