Authors’ contributions:
M.E., R.L.L. secured funding; E.L.K., R.L.L., M.E. and K.M. conceived and designed the experiments; M.E., E.L.K and N.G performed the experiments. M.E. and N.G. performed chemical analyses. M.E. and E.L.K. statistically analyzed the data. M.E. led the writing of the manuscript; M.E, R.L.L, E.L.K and K.M. contributed substantially to revisions. All authors gave final approval to the publication.