Methods
The methods described in this study are part of a larger study.28 For the purposes of this manuscript, we only included measures and procedures relevant to the current study.
ParticipantsEthics approval for this study was obtained through the local institutional review board (HREBA.CC-16-0268). Survivors of pediatric ALL, one sibling (if available, between 8-18 years of age), and one parent from each family were recruited through the Long-Term Survivor Clinic at the Alberta Children’s Hospital. Eligible families were approached during regular clinic visits by a member of the research team to introduce the study and evaluate their interest in participating. Eligibility criteria for survivors included: 1) diagnosed with pediatric ALL and received treatment; 2) 8-18 years of age at the time of the study; 3) were between 2-7 years post-treatment. Exclusion criteria included: 1) diagnosed with a developmental disorder; 2) unable to speak and read English; or 3) treated with CRT. If a survivor did not have an eligible sibling, they were not excluded from participation. Healthy controls, one sibling (if available), and one parent from each family were recruited through the community via online and community advertisements, public and private school mailing lists, and local community hubs and events. The only inclusion criteria for healthy controls and their siblings was that participants were 8-18 years of age at the time of the study. Exclusion criteria included: 1) diagnosed with a chronic illness; 2) diagnosed with a developmental disorder; 3) unable to speak and read English. Healthy controls were sex and age matched to a participant from the survivor group post-hoc.
ProcedureEligible survivors and their parent(s) were approached by a member of the study team at their regular long-term follow-up appointments. Interested families provided written consent and assent. Parents were emailed unique URL links to complete the questionnaire package online via Qualtrics and were asked to complete the package within 7 days. Relevant clinical information was collected from the medical records of all survivors enrolled in the study. Interested potential control participants contacted the study team through the email or telephone number provided on recruitment materials and were screened for eligibility. All eligible control participants completed a one-time visit at the University of Calgary. During this visit, written consent and assent was obtained, and parents completed the questionnaire package on a computer. All participants were renumerated $15 after completing questionnaires.