Renal function is associated with one-month and one-year mortality in
patients with intracerebral hemorrhage
Abstract
Background: This study evaluated short-term (1-month) and long-term
(1-year) mortality risks associated with kidney function measured by
estimated glomerular filtration rate (eGFR) levels at admission for
patients with intracerebral hemorrhage. Methods: From the Taiwan Stroke
Registry data, we identified and stratified patients with intracerebral
hemorrhage into 5 subgroups by the eGFR levels at admission: ≥ 90,
60-89, 30-59, 15-29, and < 15 mL/min/1.73m2 or on dialysis
from April 2006 to December 2016. Risks of 1-month mortality and 1-year
mortality rates after intracerebral hemorrhage were investigated by the
eGFR levels. Results: Both the 1-month mortality and 1-year mortality
rates increased as the eGFR level decreased. The 1-month mortality rate
was over 5-fold greater in patients with eGFR < 15
mL/min/1.73m2 or on dialysis than in patients with eGFR levels ≥ 90
mL/min/1.73m2 (8.31 versus 1.50 per 1000 person-days), with an adjusted
hazard ratio (HR) of 4.59 [95% confidence interval (CI) =
2.71-7.78]. Similarly, the 1-year mortality rate was 7.5-fold greater
in patients with eGFR < 15 mL/min/1.73m2 or on dialysis than
in patients with eGFR ≥ 90 mL/min/1.73m2, with an adjusted HR of 4.54
(95% CI 2.95-6.98). Conclusion: The eGFR level can be an indicator of
prognosis for patients with intracerebral hemorrhage.