Statistical analysis
Statistical analysis was done in MS Excel and XLSTAT 2020.5.1. Statistical significance of reduction was tested using one-sample Student’s t-test and Wilcoxon’s signed-rank test applied to all ten patients’ data. Statistical significance of reduction was tested using one-sample Student’s t-test. The null-hypothesis was rejected if a corresponding p-value was less than the significance level of 0.05. M - average value (mean); +/- SD - standard deviation; p – p value. All values are listed in the supplements.