αβ-barrel trimers
Type 2 structures must have an even number of subunits; however, Type 1
models can have any number. We have developed two types of α-Syn trimer
models. Although α-helical tetramers of α-Syn have gained more
attention, helical trimers have also been observed (Fig 18a). Helical
trimers may transition to α-β-barrel trimers in which the NAC domains
form a core six-stranded antiparallel β-barrel (Fig. 18b-e).