Figure 12. Models and images of mutant α-Syn annular and tubular protofibrils. (a-f) Flattened representation of two adjacent subunits of Type 2P models for a hexamer (a -c) and a decamer (d-f). Parameters of the barrels are listed below the figures. Inwardly oriented pleats composed primarily of small apolar side-chains are highlighted with black backgrounds. (h-m) EM images of four sizes of (g) A30P and (h-j) A53T annular protofibrils, and wedge representations of our models of a hexamer, octamer, decamer, and dodecamer drawn to scale. The red circles on the images represent the outer and inner APF boundaries predicted by the models. (k-m) Side views of three A53T tubular protofibrils that develop from the annular protofibrils. Schematics represent our models of how the annular protofibrils may pack end-to-end to form the tubular protofibrils. EM images were copied with modification and permission from Lashuel et al. [4].