Small Synuclein Oligomers
Some medium to large α-Syn oligomers appear to contain aggregates of smaller components [51][52,53]. The smallest of these components (other than monomers) appear as beads of ~ 4 nm in diameter that cluster or string together (Fig. 4). Spheres of this size could contain Nt and NAC domains of three or four monomers. The oligomers also appear to contain less defined regions surrounding the beads. These regions may contain less ordered portions of α-Syn oligomers, e.g., Ct domains, and disordered monomers; if so these disordered regions would contribute to experimental findings that the oligomers have a higher content of disordered structure than present within our models of the beads.