High density lipoproteins. α-Syn and β-Syn
All three familes of Synucleins interact with sphingmylein to form high
density lipoproteins [19]. These complexes are not toxic and will
form with both native and mutants of α-Syn associated with early onset
Parkinson’s disease. α-Syn and β-Syn lipoproteins assemble into stacks
of disc-shaped complexes (Figs. 13 and 14). Both discs and individual
oligomers are visiable in the EM images. The circular oligomers
frequently cluster; the diameters of most oligomers in these clusters
are consistent with our models of Type 2P tetramers and octamers if the
Ct barrels are not included.