Small Synuclein Oligomers
Some medium to large α-Syn oligomers appear to contain aggregates of
smaller components [51][52,53]. The smallest of these components
(other than monomers) appear as beads of ~ 4 nm in
diameter that cluster or string together (Fig. 4). Spheres of this size
could contain Nt and NAC domains of three or four monomers. The
oligomers also appear to contain less defined regions surrounding the
beads. These regions may contain less ordered portions of α-Syn
oligomers, e.g., Ct domains, and disordered monomers; if so these
disordered regions would contribute to experimental findings that the
oligomers have a higher content of disordered structure than present
within our models of the beads.