H63D syndrome is a serious and clinically progressive disorder of iron metabolism caused by non-transferrin-bound iron (NTBI). In 2019, after scientists from around the world joined together to form the H63D Syndrome Research Consortium (a non-profit entity), a consensus paper "H63D Syndrome" was adopted at a meeting in Oslo in December 2019. With this new paper, we summarize what the leading experts in the field know about the syndrome in 2021.

After reviewing the current literature and our systematically evaluated experience gained in daily practice, we propose a simplified action algorithm in case of nevi and other melanocytic skin lesions. Our approach is less stressful for the patients and, according to our conclusions, more economical, efficient and, above all, much safer than the recommendations currently in effect.

Multiple sclerosis (MS) is a progressive inflammatory disease of the central nervous system that normally leads to impairment and persistent disability at a rather early age. The observation that physical stress can lead to the onset of reversible neurological symptoms has in the past led to patients being discouraged from doing sports. We investigated the current status of research and conclude that this advice may be as incorrect for a majority of MS patients as recent recommendation which encourage individuals with MS to engage in all kinds of physical activity. 

Patients suffering from cataplexies have a highly significant risk of severe injury. This paper discusses (manufacturer-independent) medical devices that should be prescribed to any patient with moderate to severe cataplexy.

People who suffer from cataplexy have a significant risk of injury. This paper discusses (manufacturer-independent) medical devices that should be prescribed to any patient with moderate to severe cataplexy.

Long strictly forbidden, tele-psychotherapy has now also found its way to Germany. This article is one of the first experience reports, written a year after the liberalization of this kind of medical service in all 16 German federal countries. The Feldmann Paper explains the current situation in Germany (May 2021).

Based on an analysis of anonymized medical records from four hospitals in Asia and Africa, we succeeded in identifying symptoms typical for narcolepsy (with cataplexy) that are regularly overlooked because they are masked by the two severe leading symptoms. Our results do not differ between primary and secondary cases of narcolepsy. 

With regard to acquired melanosis of the conjunctiva, there is still neither a worldwide uniform nomenclature nor reliable data on how frequent this type of pigment disorder is. This is even more true for the estimation of the risk of progression into cancer as well as the clinical management of this entity. This short paper presents the current, partly contradictory scientific knowledge which is available.

Nicotine is best known for its troublesome role in tobacco addiction. However, in small doses, it is actually quite a potent and safe stimulant. Based on significant reports about a positive role of nicotine on narcoleptic seizures, we searched the medical literature for signals to better understand the opportunities and risks of medical nicotine use in patients with any severe form of narcolepsy.

In the case of a suspicious skin mole, the question always arises as to whether it is benign or malignant. Is it a harmless mole, a capillary malformation or a basal cell carcinoma, squamous cell carcinoma or even a melanoma? Often the nevus can already be assessed by a close examination of the lesion and a few questions regarding its development. But most important: the patients need to be informed about their condition in a simple but professional way.

H63D syndrome is a phenotype of a homozygous mutation of the HFE gene H63D, which is otherwise known to cause at most mild classical hemochromatosis. H63D syndrome leads to an iron overload in the body (especially in the brain, heart, liver, skin and male gonads) in the form of non-transferrin bound iron (NTBI) poisoning. Hallmark symptoms and causal factor for H63D syndrome is a mild hypotransferrinemia with transferrin saturation values >50%. H63D syndrome is an incurable multi-organ disease, leading to permanent disability. Our objective was to detect the prevalence of narcolepsy and narcolepsy with cataplexy in patients with H63D syndrome.

While the global community has been struggling to contain the Sars-CoV-2 pandemic, another equally deadly enemy of humankind has been out of the general public's focus for years: iatrogenically caused infections and, as a result, deaths in alarming numbers. With this White Paper, we remind the medical community that this epidemic must also be brought to an end. As a prominent and abhorrent example we chose Germany.