Acknowledgements
KB was supported by Independent Research Fund Denmark, DFF grant 5051-00140 and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 856488). AJD was supported by the U.K. Natural Environment Research Council (NERC) grants NE/S006958/1, NE/M02086X/1, NE/S005560/1, and NE/S000291/1. SC benefitted from NERC Highlight Topic funding grant NE/N006216/1 and SC acknowledges support from NERC grant NE/N003756/1 and NE/M02086X/1. CC was supported by Carlsberg Foundation (CF18-1110, ’Archives’). FL, VE and SC are members of EU COST Action DNAqua-Net (CA15219). Moreover, the authors would like to thank their collective research groups whose laboratory and bioinformatic experiences over many years contributed to the ideas, initiation and completion of this manuscript.